Studies on Enhancement of Solubility and Bioavailability of Bcs Class Ii/iv Drugs
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Physicochemical Characterization and Dissolution Enhancement of Loratadine–Hydroxypropyl-β-cyclodextrin Binary Systems
Loratadine, a Class II drug is a second generation antihistaminic agent, which is poorly water soluble with low bioavailability. Loratadine is practically insoluble in water and as such it exhibits poor variable oral bioavailability. Loratadine needs enhancement of solubility and dissolution rate to improve its oral bioavailability and therapeutic efficacy. In the present investigation, studies...
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Solubility is the process of dissolution of solid in liquid phase to give a homogenous system and is one of the important parameter to achieve desired concentration of drug in systemic circulation for pharmacological response. Dissolution rate of poorly water-soluble drugs is rate limiting step for its bioavailability so increase in bioavailability is the major challenging task in drug developm...
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One of the biggest challenges faced by pharmaceutical scientists is poor solubility and bioavailability of new chemical entities (NCEs). According to BCS classification; approximately 25% of all compounds are classified as highly soluble and permeable. Nearly 40% of the new chemical entities currently being discovered are lipophilic so poorly water soluble drugs. BCS Class II and Class IV have ...
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Solubility of drug plays critical role in achieving the optimum therapeutic levels of the drug in blood and thus bioavailability. There are many drugs of various therapeutic categories fall in BCS class II and IV as they lack solubility. For all these drugs dissolution is the big hurdle for the absorption process. Present review’s focus is mainly on novel techniques of improving the solubility ...
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BCS class II drugs pose challenging problems in their pharmaceutical product development process because of their low solubility and dissolution rates. They require enhancement in solubility and dissolution rate in their formulation development especially solid dosage forms such as tablets and capsules. Several conventional methods and new emerging technologies have been developed for formulati...
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